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KMID : 1009020100080020097
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Clinical Psychopharmacology and Neuroscience
2010 Volume.8 No. 2 p.97 ~ p.104
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Simultaneous Measurement of Dopamine Transporters and D2/D3 Receptors in Drug Naive Schizophrenic Patients
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Chou Yuan-Hwa
Hsu Ju-Wei
Huang Wen-Sheng
Lee Shin-Min
Yang An-Shoei
Yang Kai-Chun
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Abstract
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Objective: Previous single photon emission computed tomography (SPECT) studies have demonstrated that co-injection of radiotracers 99mTc-TRODAT and 123IBZM can assess both presynaptic, dopamine transporters (DATs), and postsynaptic, dopamine D2/D3 receptors, markers of dopaminergic system simultaneously. The aim of this study was to determine both DATs and dopamine D2/D3 receptors in drug na?ve schizophrenic patients.
Methods: Severn drug na?ve schizophrenic patients and eleven age-matched healthy controls were recruited. Each subject received one SPECT measurement after intravenous co-administration of 99mTc-TRODAT and 123IBZM and one brain MRI scan. A ratio equilibrium model was applied to calculate the specific uptake ratio (SUR) which corresponds to the ratio of Bmax (receptor density) and KD (affinity).
Results: The results showed that the SUR of DATs binding was not significantly different between healthy controls and drug na?ve schizophrenic patients (2.92±0.62 vs. 2.65±0.27, p=0.052) and, however, the SUR of dopamine D2/D3 receptors binding was significantly lower in drug na?ve schizophrenic patients than those in healthy controls (2.79±0.54 vs. 3.90±0.58, p=0.001). Additionally, there was a significant correlation between left and right binding for both DATs (r=0.80, p=0.003) and dopamine D2/D3 receptors (r=0.96, p=0.000) in healthy controls but not seen in drug na?ve schizophrenic patients (r=0.54, p=0.20 for DATs, r=0.70, p=0.08 for dopamine D2/D3 receptors).
Conslusion: This study provides evidences to support the idea that abnormalities of dopaminergic system in schizophrenia and further elucidates the disruption of inter-hemispheric interaction of postsynaptic and presynaptic markers.
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KEYWORD
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Schizophrenia, Dopamine transporters, Dopamine D2/D3 receptors, Single photon emission computed tomography (SPECT), 99mTc TRODAT, 123IBZ
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